Senescent endothelium generally has the ability to secrete SASP, and the ability of senescent endothelium to secrete SASP to promote tumor cell migration has been verified in different tumors [8], we make sure that the ability of HUVECs to promote tumor migration is derived from their SASP secretion, and so we identified the SASP genes that are significantly overexpressed among the endothelial cell differential genes obtained by single-cell sequencing: CXCL12, CCL2 and IGFBP5 (Fig. 5K, S2A). Here, IGFBP5 is linked to neoplasm.