In conclusion, we demonstrate that KLF4 is a key gene driving senescence in UM endothelial cells, and overexpression of KLF4 in normal endothelial cells induces senescence and promotes tumor cell migration, whereas knockdown of KLF4 in such senescent endothelial cells inhibits their senescence, and the ability to promote tumor cell migration disappears. Here, KLF4 is linked to neoplasm.