KLF4 and neoplasm: S2B, S2C). And further determined that the expression of CXCL12 in HUVECs was consistent with the expression of KLF4 and p21 (Fig. 5B, G, L, M). Combined with the evidence from previous studies [28] and the clinical prognosis of different SASP in UM (Fig. 5N, S2D), we confirmed that CXCL12 is a key factor leading to the promotion of tumor cell migration in senescent endothelial cells.