CXCL12 and neoplasm: Senescent endothelial cells significantly promote tumor cell migration by secreting CXCL12, which has been demonstrated by a large body of previous evidence [28] combined with our single-cell sequencing validation results, but the receptor for CXCL12 targeting to uveal melanoma cells is still unclear, and the lack of a suitable in vivo model of UM for validation is an issue that needs to be addressed.