PI3 kinase/AKT and RAS/RAF/MEK/ERK signaling pathways play an important role in KIT signaling [20, 21, 27], in order to know whether the two signaling pathways are involved in the regulation of ZSWIM4 expression by KIT, GIST-T1 cells were treated with PI3 kinase inhibitors or MEK inhibitors. The gene discussed is MAP2K7; the disease is gastrointestinal stromal tumor.