We found that KITV558A/WT/ZSWIM4−/− mice survive shorter than KITV558A/WT mice (Fig. 7A), and experience accelerated GIST growth (Fig. 7B), suggesting that ZSWIM4 inhibits the tumorigenesis of GISTs in vivo. The gene discussed is ZSWIM4; the disease is gastrointestinal stromal tumor.