ZSWIM4 and gastrointestinal stromal tumor: Immunofluorescence examination of clinical GISTs showed that ZSWIM4 is localized in both cytoplasm and nucleus with nucleus predominant (Fig. 5A), which was further confirmed in the examination of GISTs from KITV558A/WT mice and GIST-T1 cells by immunofluorescence examination and western blot after cell fraction (Fig. 5A, B, C).