Moreover, after treatment with imatinib, tumor volumes in KITV558A/WT mice and KITV558A/WT/ZSWIM4−/− mice were reduced by 40.6% and 45.7% respectively, and tumor weight was reduced by 42.9% and 46.1% respectively, suggesting that ZSWIM4 does not influence the sensitivity of GISTs to imatinib treatment. The gene discussed is ZSWIM4; the disease is neoplasm.