For example, the core circadian pathway members PER2 and BMAL1 serve as tumor suppressor in lung cancer [30], BMAL1 and CLOCK respectively act as tumor suppressor and oncogene in colorectal cancer [31], BMAL1 inhibits ferroptosis to increase the oncogenesis of acute myeloid leukemia [29]. The gene discussed is PER2; the disease is acute myeloid leukemia.