Tumor-educated MSCs can further activate and release the chemoprotective and immunomodulatory factors including CXCL1, CXCL2, and IL-8, favoring tumor progression [82] in which MSCs generated CXCL2, VEGF, TGF-β, and IL-6 can further raise tumor aggressive phenotype by boosting tumor angiogenesis [83]. This evidence concerns the gene CXCL2 and neoplasm.