TNF and psoriasis: Its suppressor function was evaluated in a human 3D cytokine-induced raft model, produced by the addition of TNF-a, IL-17 A, and IL-22, and in a psoriasis-like mouse (6-week-old C57BL/ 6 male mice) model, generated via the topical presentation of imiquimod (IMQ), which is a TLR7/8 ligand and a potential activator of the immune system.