In this approach, by topical delivery of siGM3S-SNA, the expression of GM3S mRNA and protein was efficiently and specifically suppressed in cultured keratinocytes (KCs), as well as both in wounded and intact mouse skin, followed by KC migration toward wound position, the phosphorylation of insulin-like growth factor-1 receptor (IGF1R) and epidermal growth factor receptor (EGFR), and fast healing of wounds in T2D mice. This evidence concerns the gene EGFR and type 2 diabetes mellitus.