The results revealed that both SNA constructs effectively decreased the expression levels of TGF-β1 protein in rabbit primary hypertrophic and keloid scar fibroblasts (in vitro), scar-derived human abnormal scar cells (human hypertrophic scar-derived fibroblasts [HSF], and human keloid scar-derived fibroblasts [KF]. The gene discussed is TGFB1; the disease is keloid.