Modified superparamagnetic iron oxide (SPIO), like Fe3O4 core with galactose (Gal) and polyethyleneimine (PEI) [Gal-PEI-SPIO], is another delivery system introduced by Yang et al. [1] for targeted delivery of therapeutic si-c-Met (siRNAs that target c-Met) to the hepatocellular carcinoma (HCC) [1]. This evidence concerns the gene MET and hepatocellular carcinoma.