IL17RA L-SNAs efficiently suppressed the expression of Il17ra, normalized the level of numerous psoriasis-related immune and proliferation markers that were overexpressed in the IMQ-induced psoriasis-like mouse model (e.g., Tnfa, S100a7a, Defb4, Il17c, Il6, Pi3, and Krt16), and decreased keratinocyte differentiation markers (e.g., Krt10, Lor). Here, PI3 is linked to psoriasis.