In addition, the potential involvement of skeletal muscle-induced myokines in facilitating SMEV uptake in PCa cells has been suggested with the recent discovery of myokine-integrin interaction [13] The interaction between αv family integrin and the myokine irisin (a cleaved form of Fibronectin type III domain containing 5 [FNDC5]) has been demonstrated in osteoblasts and adipocytes, with this interaction to increasing uptake of extracellular vesicles in these cells [13]. The gene discussed is FNDC5; the disease is posterior cortical atrophy.