OSM and posterior cortical atrophy: Further, our follow-up study examining acute exercise response showed transient elevation of circulating myokines (oncostatin M [OSM], secreted protein acidic and rich in cysteine [SPARC], IL[interleukin]-6, IL-15) after a single high-intensity aerobic exercise session in already exercise trained-patients with mCRPC accompanied by a significant reduction of PCa cell growth when cultured cells were exposed to exercise-conditioned serum [11].