ANTXR2 and early-onset autosomal dominant Alzheimer disease: Although most models showed no significant genes, the dominant PTV model showed significant case enrichment for ANTXR2 (OR = 174.57, p = 8.38 × 10–6) (Fig. 4; Supplemental Table 6; Supplemental Data), a gene associated with brain connectivity changes and Alzheimer’s disease [24].