Genetically-proxied impaired GK-GKRP interaction was associated with increased risk of MASLD (OR 14.6 per 1 mmol/L lower FPG, 95% CI 4.57–46.4, P = 5.98 × 10−6), as well as increased risk of CAD (OR 2.92 per 1 mmol/L lower FPG, 95% CI 1.78–4.81, P = 2.44 × 10−5). Here, GK is linked to coronary artery disorder.