As for complications, genetically-proxied GK activation was associated with reduced risk of CAD (OR 0.69 per 1 mmol/L lower FPG, 95% CI 0.54–0.88, P = 0.003) and a tendency for reduced risk of HF (OR 0.77 per 1 mmol/L lower FPG, 95% CI 0.58–1.02, P = 0.071). Here, GK is linked to coronary artery disorder.