CD4 and Autoimmunity: Aconitum carmichaelii Debx has been shown to boost autoimmunity, and Aconitum carmichaelii polysaccharides can increase white blood cells and lymphocytes, reverse the decreased mRNA expression of NF-кB, IL-6, and iNOS, differentiation of CD4 + FOXP3 + regulatory T cells as well as protein expression of occludin and zonula occludens [27].