Proteome profiler analysis of kidney lysates from young, old untreated and old treated mice also revealed that treatment with HK reverted the age-related increase of Pentraxin-2/SAP and Lipocalin-2/NGAL—two proteins associated with inflammation and kidney damage, respectively38,39 (Extended Data Fig. 2c,d). This evidence concerns the gene LCN2 and Nephropathy.