High-confidence AAM genes include established components of the HPG axis that are disrupted in rare monogenic disorders of puberty (CADM1, CHD4, CHD7, FEZF1, GNRH1, KISS1, SPRY4, TAC3, TACR3 and TYRO3)39 and other recently reported candidate genes (PLEKHA5, TBX3andZNF462)40,41. The gene discussed is PLEKHA5; the disease is puberty.