High-confidence AAM genes include established components of the HPG axis that are disrupted in rare monogenic disorders of puberty (CADM1, CHD4, CHD7, FEZF1, GNRH1, KISS1, SPRY4, TAC3, TACR3 and TYRO3)39 and other recently reported candidate genes (PLEKHA5, TBX3andZNF462)40,41. Here, TACR3 is linked to puberty.