C1 displayed a matrix deposition and scar formation profile whereas C2 had markers indicative of stress responses (metallothioneins), immune modulation (CCL2 and FCN3) and vascular interactions (ENG and THBD), probably reflecting diverse fibroblast phenotypes within the fibrotic niche of the IPF lungs. This evidence concerns the gene FCN3 and idiopathic pulmonary fibrosis.