Notably, the most enriched protein in L1-specific bulk secretome is interleukin 8 (IL-8), an inflammatory chemokine involved in several regenerative processes, such as skin wound healing (JIANG et al, 2012), therapeutic angiogenesis after stroke and ischemia (Choi et al, 2021; Hou et al, 2014) and osteochondral bone repair (Lin et al, 2019; Yang et al, 2018a). This evidence concerns the gene CXCL8 and ischemia.