PTK2B and neoplasm: Additionally, it has been shown that changes in the conformation of ECM could lead to changes in the ambient pressure of cells, which activate transmembrane proteins such as integrins, phosphorylate intracellular focal adhesion kinase 2 (FAK2), activate proto-oncogene sarcoma receptor coactivator (Src), and eventually activate the PI3K/AKT signaling pathway to regulate the behavior of tumor cells34.