Therefore, we aimed to investigate (a) whether the plasma dynamics of RNH1 can serve as a biomarker for worsened outcomes in mortality, renal, and hepatic organ dysfunction in septic patients; (b) the plasma dynamics of RNase 1, RNase 1 activity, and RNase 5 and their direct relationships with RNH1 during sepsis; and (c) the effect of RNH1 as a treatment on LPS-induced inflammation, non-canonical inflammasome activation, and iron homeostasis ex vivo and in vitro. This evidence concerns the gene ANG and Sepsis.