In our study, in the high-risk group, despite the presence of favorable antigenic stimulation (the PD-L1 protein expression and TMB of high-risk group is higher than low-risk group), due to the presence of mechanical and/or functional barrier, T cells may have difficulty entering the tumor parenchyma, and it only remained in the tumor stroma (the exclusion score of high-risk group is higher than low-risk group). This evidence concerns the gene CD274 and neoplasm.