For example, a prospective study assessing data from the Clinical Practice Research Datalink in UK primary care in 136,961 patients reported that the sensitivity and the specificity for any disease including infection, autoimmune disease, or cancer were 45.6 (95% CI 44.5–46.6) and 78.8 (96% CI 78.6–79.1) for CRP, and 42.0 (95% CI 40.8–43.2) and 78.6 (96% CI 78.3–78.9) for ESR [13]. The gene discussed is CRP; the disease is cancer.