A post hoc analysis of an RCT in a type 2 diabetes population undergoing inpatient haemodialysis showed that, compared with subcutaneous insulin therapy, a fully closed-loop system was associated with a significant 37.6% increase in the proportion of time when blood glucose was within the target range (5.6–10.0 mmol/l [100–180 mg/dl]), without increasing hypoglycaemia [101]. The gene discussed is INS; the disease is Hypoglycemia.