A feasibility trial in 24 adults with type 2 diabetes managed in an outpatient setting found that HCL was associated with a 14 mmol/mol (1.3 pp) HbA1c reduction, 21.9 pp TIR increase, 16.9 pp TAR reduction and 0% of time at glucose <3 mmol/l (<54 mg/dl), without a significant change in total daily insulin dose or body weight [62]. This evidence concerns the gene INS and type 2 diabetes mellitus.