INS and type 2 diabetes mellitus: A recent meta-analysis of seven RCTs assessing the efficacy of fully closed-loop systems compared with conventional insulin therapy in 390 people with type 2 diabetes showed that fully closed-loop systems improved TIR (MD +22.40 pp, 95% CI 12.88, 31.91 pp; p<0.01) and reduced TAR (MD −22.67 pp, 95% CI −30.87, −14.46 pp; p<0.01) without a significant difference in hypoglycaemia [61].