Similarly, an RCT in 26 adults with type 2 diabetes requiring dialysis in an outpatient setting showed that a fully AID system significantly increased TIR by 14.6 pp without increased hypoglycaemia compared with standard insulin therapy [58], suggesting that closed-loop systems could be a novel way to achieve safe and effective glucose management in this vulnerable population. The gene discussed is INS; the disease is Hypoglycemia.