These findings were additionally supported by the similar response pattern following a combination of α-PD-1 instead of α-CTLA-4 and a hypofractionated radiotherapy regimen (8 Gy ×3) instead of 15 Gy ×1 in the same bilateral MC38 tumor model (Supplementary Fig. 3K–O). The gene discussed is CTLA4; the disease is neoplasm.