MPPE1 and neoplasm: cDC1 depletion remained significant on day 4 after tumor IR (corresponding to day 11 after neoadjuvant DLN IR), when it was also apparent in the concomitantly irradiated DLNs: absolute cell counts normalized to the control were 112.80 ± 43.29%, 34.90 ± 15.44% and 56.85 ± 11.24% in the “TM IR + ICI”, “TM + C-DLN IR + ICI” and “TM + NEO-DLN IR + ICI” groups, respectively (Fig. 10C, D).