To determine whether FGFR3 is required for the uptake of AD-associated pathogenic tau in neurons, we exogenously injected preformed synthetic human tau fibrils (PFFs) with AAV9-siFGFR3 into tauopathy model mice, which are known to be internalized and initiate tauopathy with tau propagation52. The gene discussed is MAPT; the disease is Alzheimer disease.