Similarly, the cardiac function was reduced in endothelial cell‐specific TSPAN4 knockout MIRI mice treated with LIPUS (Figure 4E), and the effects of LIPUS were weakened in myocardial infarct area and myocardial injury (Figure 4F–H), indicating that the impairment of migrasome formation weakens the therapeutic effect of LIPUS on MIRI. The gene discussed is TSPAN4; the disease is myocardial infarction.