Posttranslational regulation of LRP1 by proteolytic shedding regulates a wide variety of cellular and physiologic functions, and dysregulated shedding is linked to various diseases including rheumatoid arthritis, systemic lupus erythematosus (89), neuro-inflammation (90), acute respiratory distress syndrome (91), obstructive sleep apnoea (92) and cancer (93, 94, 95, 96) for reviews). This evidence concerns the gene LRP1 and cancer.