APC and Sepsis: In patients with acute respiratory distress syndrome, a common complication of sepsis, two subgroups named “hyperinflammatory” and “hypoinflammatory” have been identified based on clinical data and a limited set of plasma biomarkers.90These subgroups can also be identified in patients sepsis, and in a retrospective analysis of the PROWESS-SHOCK study, evaluating the effect of recombinant human APC in patients with septic shock, the response to this therapy differed by subgroup.91