VWF and von Willebrand disease 1: In VWD, using ristocetin as an activating agent, diagnostic performance of Multiplate in most studies was excellent in all patients, except in those patients with a mild subtype 1.64, 123, 124Similar to PFA-100 and T-TAS, sensitivity was notably lower in patients with mild type 1 VWD.64, 65However, Valarche et al reported normal Multiplate results even in patients with VWD type 2A and 2M.76Notably, four out of five patients with normal results in this study had a VWF activity of ≥40%, which could potentially account for the observed low sensitivity.