Platelet deposition was found to be highly dependent on surface immobilization of plasma VWF on the polystyrene plate162and proved to be useful in detecting VWD, GT, and afibrinogenemia.163In a trial involving pediatric patients with diverse primary hemostasis defects, the assay demonstrated a notable capacity to reliably rule out bleeding disorders, with a sensitivity of 90%. This evidence concerns the gene VWF and von Willebrand disease (hereditary or acquired).