This observation aligns with expectations, since PFA is not able to detect secondary hemostasis defects, such as FVIII deficiency, which is the main outcome of type 2N VWD.24, 53, 56, 80As the PFA primarily functions as a screening tool, it does not contribute to identifying the specific subtype of VWD in any given patient.28Nor can the PFA-100 distinguish VWD from PFDs. This evidence concerns the gene F8 and hyperinsulinemic hypoglycemia, familial, 4.