Later studies confirmed high sensitivity of T-TAS in patients with VWD, especially in patients with deficiency of high molecular weight multimers.115, 116Additionally, a correlation between bleeding tendency and T-TAS outcomes was found in patients with VWD type 1.117However, sensitivity in those with mild VWD type 1 and (VWF: Ag > 25%) was limited.115As such, it was questioned whether T-TAS has added value over PFA-100 in patients with VWD. This evidence concerns the gene VWF and hyperinsulinemic hypoglycemia, familial, 4.