But among young individuals, it is one of the most prevalent cancertype.44,45 Most HL patients (80–90%) are curablewith standard chemoradiotherapy.46,47 However, someindividuals have a poor prognosis, particularly those who relapseafter receiving first-line of therapy.48 Several lymphoma types have been associated with mutations in thegenes exportin-1 (XPO1), EZH2, MYD88, BRAF, and RHOA.49 The gene discussed is RHOA; the disease is Hodgkins lymphoma.