Preoperative and postoperative ctDNA testing was used to monitor97 patients with resectable and borderline resectable PC in a studyby Yamaguchi et al.32 Regardless of thectDNA status prior to surgery, they discovered that a positive postoperativectDNA status was linked to a significantly shorter recurrence-freesurvival (RFS) for KRAS mutations namely G12D, G12 V, and G12R. This evidence concerns the gene KRAS and pachyonychia congenita.