According to studies, HCC patients’ ctDNAfrequently has mutations in genes including RAS, TERT, CTNNB1, TP53,AXIN1, and ARID1A.93,94 The majority of HCC patient’stumor burden can be determined from somatic mutation sites ctDNA,which can also reveal details about the initial cancer biopsy.93 The gene discussed is TP53; the disease is hepatocellular carcinoma.