DNA methylation atthe Gpbar1 (TGR5) has been found by Han et al. to be a potential biomarkerfor HCC patients with chronic hepatitis B (CHB).99 Serum MT1G and MT1M methylation was found in HCC patientsfar more frequently than in CHB patients or the healthy control group.100 Higher levels of INK4A promoter hyper-methylationmay serve as a biomarker for patients with HCC since they developearly in the tumor’s course.101. This evidence concerns the gene CDKN2A and chronic hepatitis B virus infection.