Although more studies are needed to clarify the potential pathogenic role for anti-HSP60 autoantibodies in enhancing inflammatory reactions induced by extracellular HSPs, the identification of immunodominant epitopes recognized by anti-FLS RA-rmAbs may pave the way for the development of innovative therapeutic approaches encompassing vaccination and tolerogenic strategies. The gene discussed is HSPD1; the disease is rheumatoid arthritis.