Liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis of a 60 kDa band of total protein detected via Western blotting by several RA-rmAbs targeting RA-FLSs identified HSP60 as one of the most abundant proteins (among >100 detected by the LC-MS/MS analysis), with a high amount of sequence coverage (68%) across the full length of HSP60 (Figure 1B). This evidence concerns the gene HSPD1 and rheumatoid arthritis.