CIT and Arthritis: Interestingly, the anti-histone RA-rmAbs were shown to improve the arthritis score in CIA mice compared with controls, an observation in line with previous work in which anti–cit-histone antibodies were shown to ameliorate joint inflammation in the CIA model, putatively by shielding the cit-histones presented extracellularly during inflammation and neutrophil extracellular traps (NETosis) from the immune system, thus preventing inflammation (25).