Moreover, together with the partial inhibition by preabsorption with HSP60 in the ELISA, we found that these RA-rmAbs had some level of cross-reactivity to other RA-associated antigens like calreticulin and vimentin, which are other known autoantigens in RA and migrate to a similar position in FLS protein extract electrophoresis. Here, HSPD1 is linked to rheumatoid arthritis.