CALR and rheumatoid arthritis: Similar to HSP60, calreticulin (CALR) gene expression was significantly higher in the lympho-myeloid pathotype in bulk synovial RNA-Seq results and in spatial association with lymphoid aggregates using GeoMx analysis of patients with established RA (Supplemental Figure 7, A–D), supporting the conclusion that stromal-derived autoantigens involved in the cellular stress response were upregulated in RA patients with the lympho-myeloid pathotype and contributed to the generation of pathogenic autoantibodies.