NPM1 and acute myeloid leukemia: As outlined in Figure 7A, we transplanted multimutational (FLT3ITD (ins46), DNMT3A, R882H, NPM1, 288FS12, and CHEK2) AML patient cells into sublethally irradiated (200 rads) NOD-scid IL2Rgnull-3/GM/SF(NSGS) mice through tail vein injection.