NRAS and acute myeloid leukemia: To assess the effect of HSN748 on the growth and survival of leukemic stem cells, we transplanted the above sample from the patient with AML (bearing the NRAS (G12D) mutation) in NSGS mice, as described in Figure 7A. To expand these cells further, we retransplanted them into secondary NSGS mice and drug treatment was initiated after 8 weeks of transplantation.