Monocytic skewing as a result of a block in differentiation is one of the cardinal features of AML, which our transplant model system phenocopies; the frequency of myeloid cells (CD11b+Gr1–) in the bone marrow of the vehicle-treated group was increased (Figure 6D), while this was normalized by HSN748 treatment. This evidence concerns the gene ITGAM and acute myeloid leukemia.