Intriguingly, the PCBP2-regulated genes with T2D-associated SNPs were primarily enriched in cellular features relating to synaptic and exocytotic vesicles (Rph3a, Syt10, Rab3c, Syndig1, Cttnbp2, Ntrk2, Myo5c; Figure 8D), further bolstering the major influence of PCBP2 on shaping gene expression important for insulin granule ultrastructure and dynamics. This evidence concerns the gene RPH3A and type 2 diabetes mellitus.