Further, the PCBP2-regulated genes overlapped those altered in human islets cultured in a type 2 diabetic milieu of palmitate and/or high glucose (Figure 8C and Supplemental Figure 18A; P = 3.068 × 10–3, P = 5.06 × 10–6) and in islets from human donors with T2D (Figure 8C and Supplemental Figure 18A; P = 3.06 × 10–3) (37–39). This evidence concerns the gene PCBP2 and type 2 diabetes mellitus.