IL18R1 and infection: With IFNγ blockade, genes in cluster 2, including IL18R1, IDO1, CXCL11, CD274 (PD-L1), and PTPN2, were similarly expressed at day 3 post-infection but were more highly expressed at day 7 compared to controls and had increased expression over the day 3 timepoint (S3 Fig).