For example, tissue factor promotes tumor progression in breast cancer, fibrosarcoma, colon carcinoma, melanoma, and pancreatic cancer [4–6], possibly by binding factor VIIa and subsequently cleaving protease activated receptor 2 (PAR2), thereby inducing the release of proangiogenic factors, and promoting cell migration and metastasis [5]. This evidence concerns the gene F2RL1 and neoplasm.