To shed more light on the lymphocyte response in the context of HbTg co-infection, we investigated the changes in Th1 and Th2 cytokines at the systemic level, as well as IFN©-producing lymphocytes (NK, NKT, CD4+ T, CD8+ T and ©δ T cells) at day 5 and day 10 post-Tg infection in different organs. This evidence concerns the gene CD8A and infection.