Overexpression of the rate‐limiting ribosome recycling factor ABCE1 or knockdown of ZNF598, which cause inefficient RQC and therefore resumption of translation by the stalled ribosome, can rescue the proteostasis failure, endolysosomal/autophagy dysfunction, and cognitive deficits in AD mouse models [99]. This evidence concerns the gene ZNF598 and Alzheimer disease.