PSEN1 and Alzheimer disease: Given our findings in the atg7iKO mice, we evaluated whether the AD-associated mutations of the APP PSEN1 double transgenic mouse model of AD [73], a model that over-expresses mutant forms of the AD-associated proteins APP (amyloid beta precursor protein) and PSEN1 (presenilin 1), lead to measurable changes in autophagy.