KMT2A and acute lymphoblastic leukemia: In contrast to the male skew in cancers associated with loss of H3K27me3-repressive marks, loss of mixed-lineage leukemia 1 (MLL1 or KMT2A) expression through chromosomal translocation results in loss of the activating mark H3K4me3 in acute lymphoblastic leukemia (ALL) (169).