Of note, multivariate Cox regression analysis showed that altered <i>RB1</i>, <i>NOTCH3</i>, <i>MGA</i>, <i>SYNE1</i>, and <i>ZFHX3</i>, as independent prognostic factors, were significantly correlated with the OS of HCC patients. Here, NOTCH3 is linked to hepatocellular carcinoma.