Thus, whether Ehmt2 is deleted from the pancreas using either the Pdx1-Cre or P48Cre/+ model, the modified transcriptional impact of acute pancreatitis compared to their counterparts with Ehmt2 intact are similar, highlighting that Ehmt2 participates primarily in preventing an enhanced injury-inflammatory repair response in this organ. Here, PDX1 is linked to acute pancreatitis.