To confirm the enhanced tissue damage response during acute pancreatitis observed with loss of Ehmt2, we performed a pairwise analysis of the pancreatitis transcriptional landscape of the Ehmt2 knockout generated either with the Pdx1-Cre (Pdx1-Ehmt2fl/fl) or P48Cre/+ (P48-Ehmt2fl/fl) -driven models. The gene discussed is PDX1; the disease is pancreatitis.