In our analysis of the upregulated and downregulated genes, we found that Ehmt2+/+ and Ehmt2fl/fl mice with acute pancreatitis exhibited significant enrichment of similar pathways, specifically genes involved in injury-inflammation through activation of the oncogenic KRAS, P53, TNFα and TGF-β signaling pathways (Figure 2E). Here, TGFB1 is linked to acute pancreatitis.