FGF21 and metabolic disease: However, subgroup analysis indicated that concurrent exercise and a duration ≥10 weeks significantly decreased FGF21 concentrations with an effect size of -0.38 (95% CI [-0.74--0.01], <i>p</i> < 0.05) and -0.38 (95% CI [-0.63--0.13], <i>p</i> < 0.01), respectively.<h4>Conclusion</h4>Concurrent exercise and longer duration may be more efficient way to decrease FGF21 concentrations in adults with metabolic disorder.