Recently, Chen et al. demonstrated that targeted loss of proline‐rich/serine coiled‐coil protein 1 (PSRC1) could affect the intestinal flora and liver FMO3, accelerate the production of TMAO, and promote atherosclerosis54, suggesting that PSRC1 could potentially regulate the intestinal microbiota and alleviate atherosclerosis. The gene discussed is PSRC1; the disease is atherosclerosis.