In PC, mRNA levels of ADAMTS1, 8 and 9 were found to be reduced in prostatic carcinoma cell lines (PC3, DU145 and LNCaP) compared to prostatic stromal cells from benign prostatic hyperplasia patients (BPH), while ADAMTS15 mRNA expression was higher in carcinoma cells and ADAMTS4 and 5 were not detectable in cancer cells but present in BPH samples[42]. The gene discussed is ADAMTS1; the disease is cancer.