ADAMTS8 and renal cell carcinoma: Indeed, the expression of ADAMTS8, 9, 12, 16, 18 and 19 was found to be reduced through methylation in the CpG islands in the promoter region in LC, BC, gastric (GC), colorectal (CRC), PDAC, prostate cancer (PC) and renal cell carcinoma (RCC)[19–28].