Overexpression of ADAMTS12 in HEK239 cells stimulated the transcriptional activity of Wnt/β-catenin, while ADAMTS12 knockdown in CRC cells decreased the expression of the Wnt/β-catenin target genes myc and cyclin D1, suggesting that ADAMTS12 might control CRC progression through the modulation of the Wnt/ β-catenin pathway (Fig. 5B), which is a key driver of CRC[101]. The gene discussed is ADAMTS12; the disease is colorectal carcinoma.