Conversely, ADAMTS12 was found to inhibit Hepatocyte growth factor (HGF)-induced EMT in Madin-Darby Canine Kidney (MCDK) cells, and mice injected with lung adenocarcinoma A549 cells overexpressing ADAMTS12 showed a significantly reduced tumour volume and size[57], indicating that ADAMTS12-dependent regulation of EMT might be tissue specific. This evidence concerns the gene ADAMTS12 and lung adenocarcinoma.