Indeed, ADAMTS4 and the ADAMTS5 fragment TS5-p45 accumulated in the nucleus of smooth muscle cells and endothelial cells, respectively, driving apoptosis[114,115]; while ADAMTS1, but not ADAMTS4 and 5, localised to the nucleus of non-transformed mammary epithelial cells and BC cells[116]. The gene discussed is ADAMTS5; the disease is breast cancer.