Notably, TREM2+ Macrophages promoted the transition of CD4+ T cells into an anti-tumor phenotype through inhibitory receptors such as PDL2 and other inhibitory receptors, while CD4_Tcm further enhanced the differentiation of TREM2+ Macrophages into a tumor-promoting phenotype via the TGF-β pathway. The gene discussed is TGFB1; the disease is neoplasm.