CDK4 and neoplasm: The tumor tissues were then analyzed by Western blotting to detect the different expression levels of proliferation (Ki67 and PCNA), apoptosis (c-Casp3, c-PARP) (Figure 5D), metastasis (vimentin), related substrate (p-PDH, HDAC1) (Figure S7E), and cell cycle-related proteins (CDC25A, CDK4, CDK6, and Rb) (Figure S7E) in each group.