The tumor-infiltrating lymphocytes (TILs) elicited by this vaccine not only maintained an activated effector phenotype but also modulated numerous suppressive elements within the TME, including regulatory T (Treg) cells, myeloid-derived suppressor cells (MDSCs), and cytokines like Interleukin 10 (IL-10) and transforming growth factor-β (TGF-β). The gene discussed is IL10; the disease is neoplasm.