Compared to MPS-II NB counterparts, the MPS-I NB samples uniquely identified in the present study exhibit a pronounced self-communication pattern which significantly sends and receives key signals including ALCAM, L1CAM, MK, and NPY. All of these signaling pathways have demonstrated to directly promote the tumorigenesis, proliferation, migration, and invasion of NB. Here, L1CAM is linked to neuroblastoma.