Based on analysis of energy metabolomics, it has been suggested that the malignant proliferation of MPS-I NB cells was remarkably supported by reprogrammed glutamate metabolism, tricarboxylic acid cycle, urea cycle, etc. Furthermore, in contrast to the MPS-II counterpart, MPS-I NB manifested a distinct tumor-promoting developmental lineage and self-communication patterns, as evidenced by enhanced oncogenic signaling pathways activated with development and self-communication. The gene discussed is IDUA; the disease is neuroblastoma.