Moreover, key pro-apoptotic proteins involved in the apoptotic mitochondrial pathway, including cleaved CASPASE-9, cleaved CASPASE-3, and BAX, had their expressions significantly upregulated after AZD7762 and etoposide treatments in their respective sensitive NB groups, with a remarkably decreased expression of the anti-apoptotic proteins BCL-2 (Figure 9 I and J). The gene discussed is BAX; the disease is neuroblastoma.