Independent risk factors for patients' mortality were COVID-19 infection, obesity, SOFA score, total number of comorbidities, WBC count, and CRP, but not infection from CRGN pathogens.<h4>Conclusions</h4>The incidence of CRGN infections in critically ill COVID-19 patients is not different from that of non-COVID-19 ICU patients. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.