The expressions of MAPK4 and related signaling molecules were detected by western blot analysis and immunofluorescence staining, and so on.<h4>Results</h4>We found that the expression of MAPK4, which was dominantly expressed in local endothelial cells (ECs), was correlated with tumor angiogenesis of NSCLC. This evidence concerns the gene MAPK4 and non-small cell lung carcinoma.