This study aimed to compare the presence of cardiometabolic risk factors in children with TS and healthy controls.<h4>Methods</h4>This is a cross-sectional study comparing patients with TS to age-matched healthy controls, regarding cardiometabolic risk factors including lipid profile, fasting glucose, insulin resistance, body composition, body mass index, blood pressure, and carotid intima-media thickness (cIMT).<h4>Results</h4>We included nine TS patients and nine controls with a median age of 13 years (9-14 years). This evidence concerns the gene INS and Timothy syndrome.