The study aims to establish and characterize a research model in NPC containing a hypoxic gene reporter imaging system that can accurately and reliably map hypoxia distribution within tumor tissue; and to investigate the effect of tumor hypoxia on DSB and synergistic effect of irradiation in combination with chemotherapy or PI3K/mTOR dual inhibitor in overcoming hypoxia-related radioresistance. The gene discussed is MTOR; the disease is neoplasm.