Furthermore, serum tumor markers showed that group M had significantly higher levels of CA125 and HE4 than group C. Serum CA125 (50.248±16.536 vs. 94.638±19.657, p<0.001) and HE4 (101.998±26.598 vs. 161.763±22.521, p<0.001) in group MD levels were significantly lower than those in group M, while treatment with naringin alone had no significant effect on serum CA125 and HE4 levels (p>0.05) (Figure 2M-N). Here, WFDC2 is linked to neoplasm.