In the meantime, the MND group exhibited a significantly lower overall p-p38/p38 ratio (0.365±0.031 vs 0.05945±0.032, p<0.001) and ERCC1 level (0.760±0.088 vs 1.187±0.149, p<0.01) compared to the MD group. Here, MAPK14 is linked to Menkes disease.