The MND group exhibited elevated levels of TLR4 protein (2.030±0.132 vs. 1.127±0.089, p<0.001), MyD88 protein (1.890±0.152 vs. 1.460±0.104, p<0.01), and the p-p65/p65 protein ratio (0.965±0.055 vs. 0.752± 0.063, p<0.01), compared to the M group. Here, MYD88 is linked to mild neurocognitive disorder.