In the MD group, the p-p38/p38 ratio (0.05945±0.032 vs 0.926±0.049, p<0.001), and the ERCC1 protein level (1.187±0.149 vs 1.905±0.126, p<0.001) showed a significant decrease compared to the M group (Figure 1D-E). This evidence concerns the gene ERCC1 and Menkes disease.