The search employed keywords such as "pyroptosis", "cancer", "tumor", "mechanism", "immunity", "gasdermin", "ICB", "CAR-T", "PD-1", "PD-L1", "herbal medicine", "botanical medicine", "Chinese medicine", "traditional Chinese medicine", "immunotherapy", linked by AND/OR, to capture the latest findings in pyroptosis and tumor immunotherapy.<h4>Results</h4>Pyroptosis is governed by a complex mechanism, with the Gasdermin family playing a pivotal role. This evidence concerns the gene GSDMA and cancer.