LOX and injury: COX inhibitors, such as aspirin, have been tested in clinical studies and overall do not decrease the incidence of DCI.49 Cytochrome P450 is also unlikely to be a major factor in arachidonic acid metabolism following SAH as there are low brain levels of cytochrome P450 and restricted expression.50,51 Together with the study by Gaberel et al.,15 12/15-LOX may be a key player in the metabolism of arachidonic acid after brain injury.