It is well-known that arachidonic acid metabolism is deleterious following cerebrovascular diseases, including SAH.42 Arachidonic acid can be metabolized by three major classes of enzymes, namely cytochrome P450, cyclooxygenase (COX), and LOX.43 COX, which promotes inflammatory response and platelet function,44,45,46,47,48 may not be able to decrease the incidence of DCI. This evidence concerns the gene LOX and cerebrovascular disorder.