The density of PDGFRα+ cells within the LES and esophagus was greater than that of ICC-IM and two distinct populations of PDGFRα+ cells, submucosal (PDGFRα-SM) and intramuscular (PDGFRα-IM), were observed (Fig. 3g–i). The gene discussed is PDGFRA; the disease is intrahepatic cholangiocarcinoma.